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Relationship between alcohol and primary headaches: a systematic review and meta-analysis

Substances such as sulfites, histamine, and tyramines are found in alcohol and may contribute to headaches as well. It has also been proposed that alcohol triggers an inflammatory response that can lead to a headache. People who cannot stop drinking should talk with a doctor about treatment for alcohol use disorder, which is a serious but treatable condition. If none of the preventative measures above work or you didn’t know alcohol triggered migraines until after the fact, there are still options available to you.

Is alcohol or another component of the drink the trigger?

However, the mechanism for how alcohol triggers migraines is still not fully understood. One theory is that it is related to the way alcohol affects brain cells. Individual sensitivity, brain receptors, and genes may influence these reactions. If both stress and alcohol are migraine triggers for you, combining them alcohol and migraine: relationship, triggers, treatment and more won’t do you any favors. In addition to this, people are sometimes more likely to drink more when they are feeling stressed and a little reckless. Migraine is a symptom of an underlying condition, and one of the elements of a migraine is a headache.

Associated Data

  • A 2015 study suggests that the inactivity of alcohol dehydrogenase 2, an enzyme that helps break down alcohol, might contribute to hangover headaches.
  • Three studies were evaluated as moderate risk, with 6 “yes” answers 44, 57, 59.
  • In a logistic regression model using attack frequency and migraine subtype as covariates, a study of 5725 females and 1061 males analyzed the sexual dimorphism of migraine triggers by calculating odds ratios.
  • To learn more about all of your migraine treatment options, visit the AMF Resource Library.
  • Only few studies 46, 48–50, 52 provided the data about the period in which alcohol drinking was considered and measured.
  • Still, in population-based studies in various countries, including the U.S., Japan and Italy, researchers found that fewer people with migraine consume alcohol than those without migraine.

People who get hangovers that trigger a migraine may also wish to avoid alcohol with high levels of congeners. Some research suggests that congeners play a role in hangovers, although factors such as inflammation also contribute. One hypothesis is that red wine causes migraine due to high levels of certain compounds called flavonols, particularly quercetin. This compound might inhibit the body’s ability to break down alcohol, leading to the buildup of a substance called acetaldehyde, which could result in headaches. Of the 1,547 participants, 783 said that alcohol was a trigger, and 195 were not sure. Seek emergency medical care if you experience severe headaches with confusion, seizures, hallucinations, extreme tremors, chest pain, or difficulty breathing.

Managing Migraine Symptoms During Flu Season: Tips and Strategies

  • Dark-colored alcohols like red wine, brandy, and whiskey may contain more of them.
  • Avoid alcoholic and sugary drinks when you have migraine, especially during an attack.
  • It’s important to work with your obstetrician and your headache doctor when you have migraine to establish a safe treatment plan.
  • Keeping a record of what you drink and other trigger factors that make an attack more likely and talking to your doctor can help.
  • Distinguishing between hangover headaches, alcohol-triggered migraines, and withdrawal headaches is crucial for appropriate treatment and long-term health management.
  • Individual sensitivity, brain receptors, and genes may influence these reactions.

The 3-step diagnostic checklist provided in this article—timing analysis, symptom pattern recognition, and red flag assessment—can help you identify which type of headache you’re experiencing and determine the appropriate response. Remember that when in doubt, especially if you’re experiencing withdrawal symptoms, professional medical consultation is always the safest choice. Reframe’s peer support community provides a platform for users to share experiences, strategies, and encouragement. (Reframe App) This community aspect can be particularly valuable for people dealing with withdrawal symptoms or trying to identify migraine triggers. Withdrawal headaches occur when someone with physical alcohol dependence stops or significantly reduces their drinking. These headaches typically begin 6-24 hours after the last drink and can persist for several days.

alcohol and migraine: relationship, triggers, treatment and more

Alcohol is a common trigger for migraines

While migraine thankfully does not affect fertility, it can complicate conversations about family planning and infertility treatments. Finding people whom you can lean on for support can help lift some of the burden of managing migraine before, during and after pregnancy. Our Move Against Migraine Facebook group is full of mothers with migraine who can offer encouragement and support throughout your journey. To learn more about all of your migraine treatment options, visit the AMF Resource Library. For help finding a healthcare provider, check out our Find a Doctor tool. Neither the interaction term nor the presence of migraine on day‐2 were significant and they were removed (one at a time) from the final model (Model 2).

Alcohol-induced headaches: Evidence for a central mechanism?

Nicotine activates and paracetamol, capsaicin, and caffeine suppress both receptors. Activation of TRPA-1 induces the release of SP and CGRP by trigeminovascular activation, explaining the generation of a migraine headache 15-17. Olfactory stimulation also leads to increased activity of the limbic system and the dorsal pons, which induces inflammatory mediator (CGRP, SP) release and activation of nociceptors and vasodilation of meningeal vessels 14. In a positron-emission tomography (PET) study of nine patients with migraine, there was activation of the cingulate cortex, visual and auditory association cortices, and dorsal pons (raphe nucleus and locus ceruleus). But only dorsal pons activation persisted after sumatriptan injection. Cingulate cortex activation reflects the emotional response to pain and activation of the visual and auditory association cortices mirrors the development of photophobia and phonophobia, respectively.

How to Manage Your Alcohol Consumption to Prevent Migraine Attacks

Keeping track of what you drink, what other migraine triggers you where exposed to (such as stress, jetlag, sleep lack etc.) and when you get a migraine can help. Therefore, if ADs are definitely confirmed a common trigger of various primary headaches, some of which with phenotypic overlap, it is more plausible that they act probably at a common central cortical or subcortical levels. Any relief experienced from red wine likely comes from resveratrol, a potentially health-boosting plant compound. However, alcohol is traditionally considered a migraine trigger, with some research suggesting that it prompts episodes in about one-third of people. Rosen said some people he treats report being triggered by simply smelling alcohol.

alcohol and migraine: relationship, triggers, treatment and more

Migraine episodes triggered by alcohol consumption typically happen within about an hour. Delayed alcohol headaches or hangovers generally take hours to start, such as the following day after a night of drinking too much. Here’s what to know about preventing migraine attacks when also drinking alcohol, plus how to treat one if it’s too late. When alcohol is a trigger for one’s usual primary headaches, the pain usually occurs within three hours of alcohol consumption. People with migraine who treat their attacks with certain drugs should avoid drinking alcohol because it may interact poorly or dangerously with their medications. When mixed with alcohol, the common migraine medication Topamax (topiramate) can cause dizziness, problems with memory, sleepiness, and even depression.

These can make symptoms worse and increase migraine risk in sensitive individuals. An older 2014 study compared 95 people with migraine with 597 people without migraine. The results indicated people with migraine had higher chances of having hangover symptoms similar to those they experienced during episodes. Headaches are one of the most common neurological symptoms related to the sensation of pain 1 and cause a decrease in patients’ quality of life 2. Headache disorders are classified according to the third edition of the International Classification of Headache Disorders (ICHD) 4, 5 as either primary headaches, secondary headaches or neuropathies and facial pains 4, 6.

Avoid alcoholic and sugary drinks when you have migraine, especially during an attack. Dark liquors and red wines may be particularly harmful due to their sugar, sulfate, tannin, and histamine content. A 2023 review indicated that the risk of migraine in people who drink alcohol is about 1.5 times lower than in those who don’t, though the studies reviewed had a high amount of bias.

The research found that 21% of people with migraine say that alcohol is a tension headache trigger, compared with just 2% of people without migraine. Mixed models obtain the differences between each individual effect and the population estimates, thus estimates from Table 4 can be adjusted to provide an individualized model for each user. Figure 1 shows the results of the predicted probabilities (median and 95% CI) of migraine attack for each of the 487 individuals.

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